The efficacy observation on leflunomide combine with total glucosides of paeony capsules for rheu-matoid arthritis
WU Ting-ting
HE Rong
LIU Jiang-nan
LI Yan
Abstract：Objective:To investigate the clinical efficacy and safety of leflunomide combine with total glucosides of paeony capsules for patients with rheumatoid arthritis. Methods:One hundred patients with rheumatoid arthritis from June 2012 to June 2014 were randomly divided into the treatment group(n = 50)and the control group(n = 50). The patients in the treatment group accepted the treatment of leflunomide and total glucosides of paeony capsules,the control group received the treatment of leflunomide only. Indicators and adverse reaction were evaluated before and after the treatment. Results:After the 12 weeks of clinical treatment,the effective rate in treatment group was 94% ,otherwise in control group was 78% ,the clinical symptoms, visual analogue scale(VAS),erythrocyte sedimentation rate(ESR),C - reactive protein(CRP),rheumatoid factor(RF)in the treatment group significantly lower than that in the control group(P < 0. 05),the rate of adverse effect in treatment group was 8% ,and 26% in control group,the liver dysfunction in control group was higher than treatment group(P < 0. 05). Conclu-sion:The effect of treating rheumatoid arthritis with leflunomide and total glucosides of paeony capsules is safe and valuable.
Keywords：rheumatoid arthritisleflunomidetotal glucosides of paeony
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 342-345 )