The influence of dexmedetomidine pretreatment for the pulmonary function in patients undergoing radical surgery for lung cancer
JI Hao-cong
GAO Xiao-feng
Abstract：Objective:To observe the effect of dexmedetomidine on pulmonary function in patients undergoing radical sur-gery for lung cancer. Methods:Sixty patients undergoing radical resection of lung cancer were randomly divided into experimen-tal group and control group,the experimental group method using dexmedetomidine pretreatment,the control group using saline placebo pretreatment. The interleukin - 1β(IL - 1 β),interleukin - 10(IL - 10)of two group was detected in 30 min after one lung ventilation(T1),90 min after one lung ventilation(T2),1 postoperative days(T3)three point,and arterial blood gas analysis . Results :Compared with the control group ,T 2 ,T 3 IL - 1 β in the experimental group decreased significantly( P <0. 05),IL - 10 increased significantly(P < 0. 05). The alveolar oxygen partial pressure(PaO2 )of experimental group was sig-nificantly higher than that in control group after surgery,while alveolar partial pressure of carbon dioxide(PaCO2 )was signifi-cantly lower than the control group(P < 0. 05). Conclusion:Dexmedetomidine pretreatment can inhibit the expression of proin-flammatory cytokines,promote anti - inflammatory cytokine release,and can improve the postoperative lung function exchange, has certain protective effect on lung function in patients.
Keywords：dexmedetomidineinterleukin - 1βinterleukin - 10blood gas analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 340-342 )