The effect of daunorubicin combined with cytarabine on acute promyelocytic leukemia
WANG Tao
MA Liang-ming
Zhu Qiu-juan
Gong Rong
Gao Zhi-lin
Tian Wei-wei
Abstract：Objective:To explore the effect of Daunorubicin combined with cytarabine on low - risk acute promyelocytic leukemia(APL)on the basis of arsenic trioxide(ATO)and all - trans retinoic acid(ATRA). Methods:The reasonable appli-cation time of three drugs was adjusted by the white blood cell in 23 newly diagnosed APL patients in low - risk group. Observe the effect of daunorubicin(DNR)combined with cytarabine on acute promyelocytic leukemia when white blood cells rised to 1 0 × 1 09 / L and2 0 × 1 09 / L . Results :There was no significant difference in the newly number of WBC between groups( P ﹥0. 05). However,the WBC average rate of rise,the highest values and DS incidence in observation group were lower than those in control group. The median CR duration in observation group(26. 3 d)was significantly earlier than that in control group (39. 6 d). There were no significant differences in occurrence rate of DIC and CR between groups(P ﹥ 0. 05). Conclusion:Ad-ministrating chemotherapy according to the white blood cell count(≥10 × 109 / L)can raise treatment efficiency of APL and ef-fectively control the disease progression.
Keywords：acute promyelocytic leukemiaall - trans retinoic acidarsenic trioxidedaunorubicincytarabine
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 170-173 )