The research of serum TSP - 1 levels in T2DM patients with kidney disease

MA Ning; XU Ning; YIN Dong; HUI Yuan; WANG Guo-feng; ZHANG Ji-ping; HAN Guan-jun

Abstract：Objective:To explore the relationship between seruM throMbospondin - 1(TSP - 1)and kidney disease in T2DM patients. Methods:269 cases were divided into T2DM patients with kidney disease group(group A,90 cases),T2DM patients without kidney disease group(group B,92 cases)and norMal controls(group C,87cases). The seruM TSP - 1 and other clinical indicators of all the cases were detected. The indexes of insulin resistance(HOMA - IR)and the islet beta cell function index(HOMA - β)were analyzed by steady state Model. Results:The seruM TSP - 1 levels in type 2 diabetes with and without kidney disease were significantly higher than those in control group(P ﹤ 0. 05). FurtherMore,aMong type 2 diabe-tes,seruM TSP - 1 level was higher in patients with kidney disease than that without(P ﹤ 0. 05). A Multivariate correlation a-nalysis showed that seruM TSP - 1 level positively correlates with FBG、HbA1c and hs - CRP(P ﹤ 0. 01),while negatively with HOMA - β and INS( P ﹤ 0 . 01 ). Stepwise linear Multiple regression revealed that HbA1 C 、FBG 、HOMA - β and INS( P ﹤0. 05)were the independent factors of seruM TSP - 1 level. Conclusion:The seruM TSP - 1 levels are elevated in T2DM with kidney diseas,suggesting that it Might play a role in the pathophysiology of diabetic nephropath,and it is significant in predic-ting the Microangiopathy of these patients.