To observe the effect of induction chemotherapy in eldly patients with acute myeloid leukemia
WANG Tao
MA Liang-Ming
ZHU Qiu-juan
GONG Rong
GAO Zhi-lin
TIAN Wei-wei
REN Rui-rui
NIU Yan-yan
Abstract：Objective:To investigate the efficacy and toxicity of CAG and DA induction cheMotherapy in eldly patients with acute Myeloid leukeMia. Methods:Twenty - one eldly patients with acute Myeloid leukeMia(AML)were divided into CAG groupand DA group. CAG group:Ara - C 10 Mg/ M2 every 12 hours,d1 - d14,aclarubicin 20 Mg/ d on d1 - d4,G - CSF 200μg/ d on d1 - d14;DA group:DNR 40 Mg·M - 2 ·d - 1 ,d1 - d3,Ara - C 100 Mg·M - 2 ·d - 1 ,d1 - d7. Results:The coMplete response(CR)rate was 46%(6 / 13)and the partial response(PR)rate was 15%(2 / 13)in CAG group and the overall re-sponse(OR)rate was 61% . The coMplete response(CR)rate was 50%(4 / 8)and the partial response(PR)rate was 13%(1 / 8)in DA group and the overall response(OR)rate was 63% . There was no statistical difference in two groups(P ﹥ 0. 05). The Main toxicities of these groups were Myelosupression and infection. The infection rate was 46%(6 / 13)in CAG group and the infection rate was 75%(6 / 8)in DA group. There was a statistical difference in two groups(P ﹤ 0. 05). Conclution:CAG regiMen were effective for the eldly patients with acute Myeloid leukeMia. CAG group has low adverse reactions and low infec-tion rate. The treatMent of stratification of individual can treated the eldly patients with acute Myeloid leukeMia.
Keywords：eldly patientsacute Myeloid leukeMiainductionefficacy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )