The clinical value of aspirin therapy combined with hormone drugs for anticardiolipin antibody posi-tive pregnancy of recurrent miscarriage

LUO Qiu-ping

Abstract：Objective:To investigate the efficacy of aspirin combined hormone therapy anticardiolipin antibody - positive recurrent miscarriage in early pregnancy,provide the basis for optimizing pregnancy anticardiolipin antibody treatment of recur-rent miscarriage. Methods:patients with recurrent pregnancy miscarriage from August 2012 to August 2013 in hospital were 72 cases for the object. On the basis of protection of the patient's right to know,on the basis of voluntary patients divided into two groups and the control group of 36 cases. In determining pregnancy to pregnancy three - month period,the control group were injected daily human chorionic gonadotrophin 1 000 ~ 2 000 U. Observation group on the basis of the control group,after confir-ming the pregnancy,oral aspirin and anti - cardiolipin antibodies prednisone until two consecutive negative stop medication mo-nitoring. Follow 1 year,understand the patient pregnancy and birth outcomes. Results:The cure,the number of valid and invalid cases were 26,3,7 cases,recovery rate and the total effective rate of 72. 2% and 80. 6% cure rate and total effective rate was significantly higher(χ2 was respectively 19. 835 and 18. 627,P < 0. 05). Observation group,nausea,abdominal pain,headache, fatigue,allergic skin rashes have 1,0,0,2,1 cases of adverse reactions was 11. 1% ,compared with no significant difference(χ2= 2. 567 with the control group,P > 0. 05). Fully comply with the observation group,the basic compliance and non - compli-ance from the number of cases there were 28,6 and 2 cases,compliance rate was 94. 4% . Observation group was significantly higher treatment compliance rate(χ2 = 6. 203,P < 0. 05). Conclusion:The anti - cardiolipin antibodies in patients with recur-rent miscarriage in early pregnancy positive hCG treatment based on line aspirin hormone therapy can improve the success rate of pregnancy,to improve pregnancy outcomes,avoid miscarriage,premature birth,get better treatment compliance,has important value in clinical use,worthy of promotion.