The operational study on midazolam combine with dezocine and pethidine

ZHOU Zhi-cheng; HUANG Shen-an; FU Suo-lin; QING Jian-bin

Abstract：Objective:To investigate the clinical efficacy of intravenous anesthesia using dezocine combined with midazo-lam in patients undergoing painless gastrointestinal endoscope. Methods:Eighty patients who voluntarily required painless gas-trointestinal endoscope were randomly divided into 2 groups(n=40). GroupⅠwas induced by midazolam 5 mg and pethidine 50 mg;Group Ⅱwas induced by midazolam 5 mg and dezocine 50 mg. Before-treatment,under-surgery,weaken-up,pulse oxygen saturation,heart rate were recorded. Patients lost consciousness tim,drug withdrawal eye opening time were recorded. Adverse reactions associated with anesthesia were observed in intraoperative and postoperative. Analgesic effect were observed. Results:Patients lost consciousness time in both groups had no signifcant differences(P﹥0. 05). pulse oxygen saturation,heart rate and awake time in GroupⅡhad better than GroupⅠ(P﹤0. 05). The incidence of intraoperative apnea and postoperative discomfort in groupⅠ were significantly higher than group Ⅱ(P﹤ 0. 05). Analgesic effect in both groups had no signifcant differences(P﹥0. 05). Conclusion:Dezocine combined with midazolam in induced anesthesia has better analgesia effect and safety.