Correlation analysis on the hyperhomocysteinemia and acute cerebral infarction

GE Jian-xin; Xu Jin-ming

Abstract：Tostudytherelevancebetweenhyperhomocysteinemia(Hcy)andacutecerebralinfarction.Meth-ods:One hundred and fifty inpatients with acute cerebral infarction were selected as the observation group and 150 clinical pa-tients with hypertension contemporaneous were selected as the control group. Patients of the two group all had fasting Hcy test and their results were compared. To divide 150 inpatients with acute cerebral infarction into high Hcy group(88 cases)and normal Hcy group(62 cases). Neurological deficit scores(NIHSS)of the two group were detected when the patient was admit-ted and four weeks after onset. Results:Hyperhomocysteinemia was 58. 7% in the observation group while 15. 3% in the con-trolgroup . Fasting Hcy of the observation group was( 3 1 . 2 6 ± 4 . 6 1 )μmol/ L . while that of the control group was( 1 5 . 9 2 ± 3. 43)μmol/L(P﹤0. 01). NIHSS had no statistical significance when patients were admitted(P﹥0. 05). But four weeks af-ter onset,NIHSS of the high Hcy group was higher than the control group(P﹤0. 01). Conclusion:Hyperhomocysteinemia is important risk factor of acute cerebral Infarction. The patients with acute cerebral Infarction show the poor prognosis while they have higher Hcy. Active intervention to hyperhomocysteinemia will help to prevent acute cerebral Infarction or improve progno-sis of patients with acute cerebral Infarction.