The clinical study on LDL/HDL and oxidative stress of hemodialysis coronary heart disease

WANG Kai

Abstract：Objective:To discuss the clinical significance of low density lipoprotein(LDL)/ high - density lipoprotein (HDL)and the oxidative stress in the hemodialysis patients with coronary heart disease. Methods:Date of all hemodialysis pa-tients with coronary heart disease in the hospital during the period of January 2010 to December 2013 were analyzed with a ret-rospective method. 33 hemodialysis patients without coronary heart disease as Control group,20 hemodialysis patients with coro-nary heart disease as observation group. LDL,HDL,erum protein oxidation product late(AOPPs),serum superoxide dispropor-tionation enzyme(SOD)and malondialdehyde(MDA)of patients were detected in etc. Results:There were statistically signifi-cant differences in ratio of HDL and LDL/ HDL between two groups(P ﹤ 0. 05),there were statistically significant differences in SOD,MDA and AOPPs between two groups(P ﹤ 0. 05). Hint:LDL in patients with coronary heart disease increased signifi-cantly,and HDL lower significantly,in the same time level of product of oxidative stress rised obviously. The regression equa-tion was obtained:y = 6. 884 - 4. 811X2 + 1. 249X3 - 0. 057X4,the results showed that a relationship exist among the ratio of LDL / HDL and LDL,HDLand SOD. The standard regression coefficient show that relationship between ratio of LDL / HDL and LDL was the largest. Conclusion:There may be a certain correlation between oxidative stress and change of LDL/ HDL ratio in hemodialysis patients with coronary heart disease.