The clinical observation of the effect of valsrtan and benazepril on the proteinuria and renal function in chronic glomerulonephritis
WEI Na
Abstract：Objective:To investigate the effect of angiotensin - converting enzyme inhibitor(ACEI)combining with angio-tensin receptor blocker(ARB)on chronic glomerulonephritis. Methods:A randomized control trial was carried out in sixty - five chronic glomerulonephritis patients,who were divided into ACEI group,ARB group and combined group. The ACEI group re-ceived lotensin,and the ARB group received valsartan,while the combined group received therapy of lotensin and valsartan. Clinical data were collected in the beginning,3rd month,6th month,9th month. Results:Proteinuria of 24 h and blood pressure were significantly decreased after 9 month therapy in all groups patients(P ﹤ 0. 05),while the GFR and the level of serum po-tassium in these patients remained the same after statistical analysis(P ﹥ 0. 05). Combined therapy had the most noticeable an-tiproteinuric and blood pressure lowering effect,while renal function improvement,the level of serum potassium and the mani-festations of side effects in combined group were similar to those in other two groups(P ﹥ 0. 05). Conclusion:ACEI combining with ARB has better anfiproteinufic and blood pressure lowering effect.
Keywords：renin - angiotensin systemblood pressureproteinuriaangiotensin - converting enzyme inhibitor
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 486-488 )