The comparsion of different does of creatinine phosphate sodium for myocardial preservation of the patients with valve replacement operation

CHANG Liang; YAN Zi-xing; MA Jie

Abstract：Objective:To observe the comparison of the effect of myocardial preservation of the patients who are infused different does of creatinine phosphate sodium(CP)before the valve replacement operation. Methods:Thirty patients who need a single valve replacement operation are divided into two groups at random,the experimental group is infused 4 grams of creati-nine phosphate sodium every day,the matched group is infused 2 grams of creatinine phosphate sodium every day,two groups all are infused creatinine phosphate sodium two days until the day before the operation. To observe the heart rebeating situa-tion,the length of blocking time,the length of the parallel cycle time of the patients of two groups during the operation,and the situation of the Intensive Care Unit stay. To compare with the test results of creatine kinase(CK),creatine kinase isoenzyme (CK - MB),cardiac troponinI(cTnI)of the patients of the two groups before the operation,1 hours after opening aorta,24 hours after the operation. Results:The heart rebeating rate of the experimental group is higher than the matched group,and the dosage of the inotropic agent of the experimental group is less than the matched group after the operation,and the concentration of the myocardial enzyme of the experimental group is lower than the matched group. Conclusion:the effect of myocardial pres-ervation of the patients who are infused 4 grams of creatinine phosphate sodium every day is stronger than the patients who are infused 2 grams of creatinine phosphate sodium every day.