Bidirectional two-sample Mendelian randomization study of causal relationships between mental disorders,insomnia,and irritable bowel syndrome
HE Zhean
DONG Chaoqun
HUANG Yingying
LIN Jing
LU Xiaoyi
MAO Xinnan
DAI Shimeng
SONG Hailu
XU Mengli
JIANG Sisi
Abstract：Objective:To analyze the causal relationships between mental disorders,insomnia,and irritable bowel syndrome(IBS)using a bidirectional two-sample Mendelian randomization(MR)approach.Methods:The primary analysis was conducted using the random-effects inverse variance weighted(IVW)method on genome-wide association study summary data.Heterogeneity was assessed using Cochran's Q statistic.The horizontal pleiotropy was tested using the intercept from MR-Egger regression.Results:Forward MR analysis revealed that major depressive disorder,schizophrenia,and insomnia were positively associated with the increased risk of IBS(all P<0.05).Reverse MR analysis indicated that IBS was positively associated with the increased risk of major depressive disorder and insomnia(all P<0.05).Cochran's Q test in the forward MR analysis showed heterogeneity in the causal estimates for the genetic instruments of schizophrenia,insomnia,and bipolar disorder,while no heterogeneity was observed for other outcomes.MR-Egger regression indicated no significant horizontal pleiotropy for any of the results(P>0.05).Conclusion:Major depressive disorder,schizophrenia,and insomnia have causal associations with IBS.
Keywords：mental disordersinsomniairritable bowel syndromeMendelian randomizationcausal relationship
Publication Date：2026-03-25
Online Publishing Date：2026-03-26(First online date of this platform, not the publication date of the document)
Pages：13( 881-893 )