Development of patient-reported outcomes measurement system-liver transplantation core domains

CHEN Xiao; ZHANG Yuxia; ZHOU Haiying; XIAO Wenjie; WEI Li; ZHAO Yi; LIU Yujing; QIU Jie; YU Jingxian

doi:10.12102/j.issn.1009-6493.2025.19.005

Abstract：Objective:To understand the postoperative health distress of liver transplant patients,and to establish the core domains of the liver transplantation-specific patient-reported outcome measurement system.Methods:From June 2023 to June 2024,a research group was set up.A first draft of core domains was initially formed through literature analysis,patient interviews,and content analysis of medical records.Through Delphi expert consultation,the suitability of each field was evaluated and revised from the importance of each field and the degree of suitability for patient self-report two aspects,to form patient-reported outcomes measurement system-liver transplantation core domains.Results:A total of 19 experts were consulted.100%of questionnaires were returned in the three rounds of correspondence.The authority coefficients of the experts were 0.91.The Kendall's harmony coefficients in each round were 0.423,0.192,and 0.205 respectively.The coefficients of variation for each evaluation concept were 0.08-0.42,0.13-0.39,and 0.05-0.20.After three rounds of consultation,the core domains of self-reported outcome measurement for liver transplant patients were finally clarified,including physiological health,psychological health,social health and overall health four dimensions,covering 22 measurement concepts.Conclusions:The core domains of self-reported outcome measurement for liver transplant patients established are scientific and reasonable,which could help promote the establishment of a liver transplant specific patient-reported outcome measurement system.