Development trajectory of quality of life in patients with PICC-associated skin impairment and its influencing factors
QI Rong
ZHU Hongyu
KE Xi
QING Jing
XIONG Qian
LUO Huiyu
Abstract：Objective:To explore the developmental trajectory of quality of life(QOL)in patients with peripherally inserted central catheter(PICC)-associated skin impairment(CASI)and to analyze its influencing factors.Methods:A total of 162 patients with PICC-related CASI from a tertiary tumor hospital in Fujian province were enrolled.General information questionnaires,the Contact Dermatitis Assessment Scale,and the Dermatology Life Quality Index(DLQI)were used for longitudinal assessments at three time points:at the onset of CASI(T1),one month post-onset(T2),and two months post-onset(T3).A latent class growth mixture model(GMM)and multinomial logistic regression were employed to analyze influencing factors.Results:The QOL scores of CASI patients at T1,T2,and T3 were(10.08±4.89),(12.65±4.33),and(15.09±6.19),respectively.The developmental trajectories of QOL were categorized into three groups:moderate impact-stable(50.6%),high impact-improving(7.4%),and moderate impact-worsening(42.0%).Regression analysis indicated that age,number of underlying diseases,delayed catheter maintenance,and contact dermatitis were significant influencing factors(P<0.05).Conclusions:The QOL of CASI patients exhibits heterogeneous developmental trajectories influenced by disease progression.Healthcare providers should develop targeted nursing interventions based on these factors to improve patients' QOL.
Keywords：catheter-associated skin impairmentquality of lifePICCdevelopmental trajectoryinfluencing factorslatent growth mixture model
Publication Date：2025-09-10
Online Publishing Date：2025-09-12(First online date of this platform, not the publication date of the document)
Pages：7( 2874-2880 )