The impact of comprehensive prevention and control measures on the trend of nosocomial infection rates based on interrupted time-series analysis
XU Ronghui
YANG Xiaowen
CHEN Limin
Abstract：Objective:To investigate the impact of comprehensive prevention and control measures for corona virus disease 2019 on the trend of nosocomial infection rates using interrupted time-series analysis.Methods:A total of 2 301 patients with nosocomial infection from a tertiary grade A general hospital in Shanxi province were selected as subjects from February 2018 and January 2022.The period from February 2018 to January 2020 was defined as the pre-pandemic phase,and the period from February 2020 to January 2022 was defined as the pandemic control phase.The routine infection control measures was employed at the pre-pandemic phase,while comprehensive prevention and control measures for corona virus disease 2019 was employed at the pandemic control phase.Interrupted time-series analysis was used to evaluate trend of nosocomial infection rates before and after the implementation of comprehensive prevention and control measures.Results:The segmented linear regression model showed that β1=0.000,P=0.939;β2=-0.032,P=0.773;β3=-0.025,P=0.015.There was no statistically significant differences(P>0.05)in β1,β2 and β3 for the neurosurgery department and ICU.There was no statistically significant(P>0.05)in β1 and β2 for the hematology department,but there was statistical significance(P=0.008)in β3.There was statistically significant(P<0.05)in β1 and β3 for the gastrointestinal surgery,but there was no statistically significant(P=0.141)in β2.There was statistically significant(P<0.05)in β1 and β2 for the neurology department,but there was no statistically significant(P=0.271)in β3.Conclusions:Comprehensive prevention and control measures for corona virus disease 2019 exerted long-term effect on reducing nosocomial infection rates.The incidence of nosocomial infection is gradually decreasing,but variations existed across departments.
Keywords：nosocomial infectioncorona virus disease 2019epidemic prevention and controlinterrupted time-series analysiscomprehensive prevention and control measures
Publication Date：2025-03-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 936-940 )