Investigation of symptoms and coping styles of Parkinson's disease patients with different clinical stages

ZHAO Wanyi; KANG Fengying; TIAN Yuling; HAO Bin; LI Li; WU Jing; ZHAO Hua

doi:10.12102/j.issn.1009-6493.2025.04.012

Abstract：Objective:To investigate the occurrence of motor symptoms and non-motor symptoms in patients with different clinical stages of Parkinson's disease,to understand the characteristics of coping styles in patients with different clinical stages of Parkinson's disease,and to analyze the correlation between coping styles and motor symptoms and non-motor symptoms.Methods:From March to October 2023,a total of 190 patients with Parkinson's disease were selected from the neurology department of a tertiary grade A hospital in Shanxi province.The basic data of the patients were collected,the clinical stages of the patients were divided by the modified Hoehn-Yahr(H-Y)staging scale,and the motor symptoms of the patients were evaluated by the Unified Parkinson Disease Rating Scale(UPDRS).The Pittsburgh Sleep Quality Index(PSQI),Montreal Cognitive Assessment(MoCA),Hamilton Anxiety Scale(HAMA),Hamilton Depression Scale(HAMD),Modified Apathy Evaluation Scale(MAES),King's Parkinson's Disease Pain Scale(KPPS),and the Argentina Hyposmia Rating Scale(AHRS)were used to evaluate the patients'non-motor symptoms from four aspects:sleep,cognition,mental function,and sensation.The Medical Coping Modes Questionnaire(MCMQ)was used to evaluate the coping style of the patients,and the correlation between the coping style and motor and non-motor symptoms was analyzed.Results:Among 190 patients with Parkinson's disease,138 patients had an early stage,35 patients had a middle stage,and 17 patients had an advanced stage.The total score of avoidance dimension in early Parkinson's disease patients was positively correlated with pain(P<0.05)and negatively correlated with smell(P<0.05),and the total score of yield dimension was positively correlated with sleep(P<0.05).The total score of face dimension was positively correlated with cognition in patients with middle and advanced Parkinson's disease(P<0.05).Conclusions:The more negative coping styles in early Parkinson's disease patients choose,the higher the degree of pain and the worse the quality of smell and sleep.The more active coping styles in patients with middle-and advanced-stage Parkinson's disease chose,the higher their cognitive level.Caregivers should develop personalized sleep plans and medication regimens to enhance patients'rehabilitation and cognitive training and improve non-motor symptoms in patients with Parkinson's disease.