Predictive value of systemic immune-inflammation index and prognostic nutritional index for the prognosis of advanced prostate cancer patients
JIANG Qin
ZHOU Min
WANG Yuan
YIN Dan
ZHANG Xinyue
Abstract：Objective:To explore the value of systemic immune-inflammation index(SII)and prognostic nutritional index(PNI)in predicting the prognosis of advanced prostate cancer patients.Methods:A retrospective study was conducted on 96 patients with advanced prostate cancer admitted to People's Hospital of Wenjiang from 2013 to 2018.Patient medical records were collected and their survivals were followed up,including overall survival(OS)and progression free survival(PFS).Receiver operating characteristic(ROC)curves were used to analyze the area under the curves(AUC)and the optimal cutoff value of SII and PNI predicting patient prognosis.The Kaplan-Meier method was used to draw survival curves,Log-rank test and Cox regression analysis were used to investigate the influencing factors of patient OS and PFS.Results:The median follow-up time was 54(38,62)months in 96 objects,with 54 deaths(56.25%)during the follow-up period.The median overall survival was 50(33,61)months with the 3-year and 5-year OS survival rates at 70.83%and 45.83%,respectively.The median progression free survival was 45.00(27.25,56.75)months with the 3-year and 5-year PFS survival rates at 61.46%and 43.75%,respectively.The AUC for predicting patient prognosis using SII and PNI were 0.699 and 0.904,with the optimal cutoff values at 671.70 and 46.35.The actual survival time of the SII≥671.70 group was shorter than that of the<671.70 group,while the actual survival time of the PNI≥46.35 group was longer than that of the<46.35 group(P<0.05).Multivariate Cox regression showed that AJCC stage at Ⅲ was a protective factor for patients'OS(HR=0.562,95%CI 0.349-0.748,P=0.011),SII≥671.70(HR=2.427,95%CI 1.731-6.109,P<0.001)and PNI<46.35(HR=10.869,95%CI 5.311-22.244,P<0.001)were risk factors for patients'OS.AJCC stage Ⅳ(HR=2.035,95%CI 1.404-5.072,P=0.014)and PNI<46.35(HR=10.344,95%CI 5.080-21.062,P<0.001)were risk factors for patients'PFS.Conclusion:PNI,SII,and AJCC staging are predictive factors for OS in advanced prostate cancer patients,and PNI and AJCC staging are also predictive factors for PFS in patients.
Keywords：prostate cancersystemic immune inflammation indexprognostic nutritional indexKaplan-Meier methodprognosisinfluencing factors
Publication Date：2025-02-09
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 353-360 )