Intervention effect of intermittent hand-foot hypothermia therapy with different temperatures on chemotherapy-induced peripheral neurotoxicity for breast cancer
LI Ran
GUO Dongxue
ZHOU Lizhi
ZHANG Zirui
Abstract：Objective:To evaluate the effect on chemotherapy-induced peripheral neurotoxicity(CIPN),hand and foot syndrome(HFS),and quality of life in breast cancer patients treated with intermittent hand and foot hypothermia at different temperatures.Methods:A total of 72 patients with breast cancer admitted to a tertiary grade A hospital in Tangshan city from Aug 2022 to May 2023 were selected as research subjects and randomly divided into study groups 1 and 2,with 36 cases in each group.During 15 minutes chemotherapy,before and after each infusion of taxoid drugs,both groups received intermittent hand and foot hypothermia therapy.Study group 1 and study group 2 wore-10～0℃ and-30～20℃ freezing gloves and foot covers,respectively.Differences in CIPN,HFS and quality of life,and hypothermia tolerability and safety were evaluated before intervention and after second,fourth and sixth cycles.Results:Frequency and severity of CIPN and HFS in study group 2 were lower than those in study group 1 after 4 and 6 cycles of intervention,and scores of physical function,emotional function,social function,general health,fatigue and insomnia were lower than those in study group 1,with statistical significance(P<0.05).There were no withdrawals from the study due to intolerance in either group.Conclusion:Intermittent low-temperature hand-foot hypothermia can effectively prevent the occurrence and severity of CIPN and HFS and improve patients' quality of life.
Keywords：intermittent hand-foot hypothermia therapybreast cancerchemotherapy-induced peripheral neuropathyCIPNhand-foot syndromeHFSquality of life
Publication Date：2024-10-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 3398-3402 )