Predictive ability of postoperative delirium and serum interleukin-6 on postoperative cognitive dysfunction in patients after coronary artery bypass grafting
PENG Tingting
DENG Xun
WU Ying
ZHANG Shan
Abstract：Objective:To investigate the role of postoperative delirium(POD)and serum interleukin-6(IL-6)in predicting postoperative cognitive dysfunction(POCD)in patients undergoing coronary artery bypass grafting(CABG).Methods:187 patients in intensive care unit of cardiac surgery were enrolled by convenience sampling.The cognitive function was measured by the Mini-Mental State Examination.The Logistic regression was used to determine the predictive value of POD and IL-6 to POCD,and areas under the curve(AUC)of the receiver operation characteristic curve was used to evaluate the predictive ability of the predictors to POCD.Results:The incidence of POCD was 37.91%.Multivariate Logistic regression analysis showed that the risk of POCD in POD patients increased by 3.655 times(OR=3.655,95%CI 1.014-13.182).Patients with high IL-6 levels(≥830.50 pg/mL)at the 6 hours after surgery had a 5.042 fold increased risk of developing POCD(OR=5.042,95%CI 1.480-17.178).The predictive power of the two factors was stronger in the elderly than in the non-elderly(P<0.05).Conclusions:POD and high IL-6 level at the 6 hours after surgery are effective indicators for predicting the occurrence of POCD.Healthcare providers should pay more attention to the screening of perioperative risk factors for POCD,and provide targeted interventions.
Keywords：coronary artery bypass graftingdeliriumcognitive dysfunctioninterleukin-6
Publication Date：2024-04-10
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1190-1195 )