Clinical research on influence of varying degrees of hypothermia on immune function of patients during hepatectomy
Abstract：Objective:To probe into the effect of different degrees of hypothermia on immune function of patients with partial hepatectomy,and provide the basis for temperature care of surgical patients.Methods:A total of 160 cases of liver cancer patients with low temperature partial hepatectomy were divided into group A(T<35.0 ℃ 41 cases),group B(T35.0 ℃~35.5 ℃,85 cases) and group C(T35.6 ℃~35.9 ℃,34 cases).T cell subsets and neutrophil absolute value(NEU) were compared among 3 groups before operation and on 1st day and 5th day after operation.The levels of interleukin-2(IL-2) and interleukin-6(IL-6) were compared before operation and on 1st day and 2nd day after operation.Results:There was statistically significant difference in level of CD3+,CD4+,CD8+,IL-2,IL-6 on the 1st d after operation and level of IL-2 and IL-6 on the 2nd day after operation in three groups(all P<0.05).the level of CD3+ and CD4+ and IL-2 on 1st day after operation in group A were lower than those in group B and C,the level of CD8+ and IL-6 were higher than those in group B and C.There was statistically significant difference in time effect and interaction effect of CD3+,CD4+,CD8+(all P<0.05).There was statistically significant difference in intergroup effect,time effect and interaction effect of IL-2 and IL-6 (all P<0.05).Conclusion:T<35.0 ℃ had a great influence on the immune function of patients,patients with partial hepatectomy for liver cancer,the body temperature should be strengthen to prevent severe hypothermia and promote postoperative recovery.
Keywords：hepatocellular carcinomaintraoperativehypothermiaimmune functionT lymphocyte subsetsneutrophils
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 2477-2480 )