Effect of normal saline instead of ethanol skin disinfectant: a systematic review
Yuan Ying
Geng Li
Abstract：Objective:To evaluate the effect of normal saline instead of ethanol disinfectant in the skin test.Methods:Randomized controlled trials (RCTs) on using normal saline as skin disinfectant instead of ethanol in skin test were searched among Cochrane Library,Chinese Journal of Biotechnology,VIPs,Wan Fang,PubMed Data Resource System.The quality evaluation of RCTs was carried out and valid data was extracted.RevMan 5.3 software was used for meta-analysis.Results:A total of 11 RCTs were included.Results of 10 RCTs showed that normal saline as skin disinfectant could reduce the positive rate of skin test results[OR=0.43,95%CI(0.23,0.81),P=0.009].3 studies showed that the false positive rate of normal saline group was lower than that in ethanol group [OR=0.12,95%CI(0.02,0.79),P=0.03].3 studies showed that sensitivity after skin test had no differences between the normal saline group and ethanol group [OR=0.80,95%CI(0.37,1.70),P=0.56].Conclusion:Normal saline instead of ethanol as skin disinfectant could effectively reduce the positive rate and false positive rate of skin test,and there was no statistically significant difference in allergic rate after treatment.However,since the quality of the included studies was not good,the effect of normal saline instead of ethanol as skin disinfectant still required a large sample of high quality randomized controlled trials to further verify.
Keywords：normal salineethanolskin testskin disinfectionpositive rateallergic reactionMeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1595-1598 )