Study on influence of sodium Darshensu on expression of ICAM-1,TNF-α and MPO in rats with pressure ischemia-reperfusion injury
Wu Jing
Shen Cuizhen
Abstract：Objective:To explore the protective effect and mechanism of Salvianolic acid A sodium (SDSS) on rats with pressure ischemia-reperfusion injury.Methods:A total of 50 male SD rats were randomly divided into the blank group,model group,and SDSS low-dose group,middle-dose group and high-dose group.The rats in the low-dose,middle-dose and high-dose groups received the preventative use of SDSS.After a week,using the self-made pressure device was used to establish a model of ischemia-reperfusion injury,the expression level of ICAM-1,TNF-α,and MPO in each group were observed by enzyme-linked immunosorbent assay(ELISA).Results:Compared with the blank group,the levels of ICAM-1,TNF-α,and MPO in all experimental groups were significantly higher than those in blank group (P<0.05).Compared with the model group,the level of ICAM-1,TNF-α,and MPO in rats injected with SDSS were significant lower (P<0.05),which was depended on the dose.Conclusion:Preventative use of SDSS had a protective effect on pressure sore ischemia-reperfusion injury,and it could effectively prevent inflammatory and oxidative stress damage of skin tissue.
Keywords：pressure soresischemia-reperfusion injurysodium DanshensuSDSSratsICAM-1TNF-αMPO
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1576-1578 )