A Meta analysis of short term high dose atorvastatin to prevent contrast induced nephropathy after coronary angiography
Huang Yanqiu
Zhao Huihua
Abstract：Objective:To investigate the effect of perioperative short term high dose atorvastatin to prevent contrast induced nephropathy (CIN)after coronary angiography.Methods:The keywords were used such as“atorvastatin/statins/statin”,“contrast induced nephropathy,CIN,nephrotoxicity,kidney failure”,and “con-trast,contrast medium”to search NGC,the Cochrane Library,the Joanna Briggs Institute Library(JBI),Em-base,MEDLINE,CBM,VIP,CNKI,and the Wanfang database to retrieve randomized controlled trials(RCTs). Two reviewers evaluated the quality of all RCTs and extracted their data;RevMan 5.0 was used for the meta analysis.Results:A total of 2 509 patients across 12 RCTs were included in this study.The patients in atorvasta-tin group were administered 40 mg or 80 mg of atorvastatin once before surgery.The Meta analysis showed that after surgery,the incidence of CIN(P <0.000 01)and the case number of patients who required hemodialy-sis(P =0.03),serum creatinine(P <0.000 01),and serum cystatin C(P <0.000 01)were significantly lower in atorvastatin group than these in control group.Conclusion:Short term high dose atorvastatin could reduce the incidence of CIN and the risk of hemodialysis after coronary angiography.
Keywords：coronary angiographystatinsatorvastatincontrast induced nephropathy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 3872-3877 )