Influence of two different methods of Rivaroxaban and intermittent pneumatic compression pump combined with e-lastic socks on coagulation function of patients

Feng Chengcheng; Zhang Zhengfeng; Luo Chunmei

doi:10.3969/j.issn.1009-6493.2016.27.009

Abstract：Objective:The aim was to compare effects of Rivaroxaban and intermittent pneumatic compression pump combined with elastic socks on the coagulation function of patients with venous thromboembolism after lumbar fusion operation.Methods:A total of 158 patients after lumbar fusion operation in our hospital from March 2014 to September 2014 were randomly divided into group A(n=85)and group B(n=73),Patients in group A were taken orally Rivaroxaban for 7 days continuously,12 h after surgery 10 mg per day.Patients in group B were used intermittent pneumatic compression device,30 min each time,2 times a day,from the first postoperative day to postoperative 7 days.And double lower limbs long legs elastic socks were used.Preventive measure of all patients were stopped at 7 d after operation.Coagulation six items prothrombin time(PT),activa-ted partial thromboplastin time(APTT),antithrombin(at),D dimer,thrombin time(TT),fibrinogen(FIB) were detected on before operation and postoperative 7 days.Double lower limb blood vessel ultrasound examina-tion were dene.After operation,we should observe and record 48 h drainage,pay attention to bleeding complica-tions,lower limb swelling and other venous thromboembolism(VTE)signs.Results:No VTE and no bleeding complications occurred 7 d after operation in two groups.There were no significant differences in 48 h drainage, PT,APTT and AT between the two groups.In group A and group B,D dimer on postoperative 7 days were in-creased 3.6 times and 7.4 timesthanthat of before operation.And there was statistically significant difference between two groups and within groups(P<0.05).In group B and group A,FIB were increased by 49.9% and 51.8% respectively.There was no significant difference between two groups on postoperative 7 days(P>0.05). There were statistically significant differences between the postoperative 7 days and before operation(P<0.05).TT on postoperative 7 days was lower than that of before operation 9.4% in group A.There was no change between postoperative 7 days and before operation in group B.There was no significant difference within groups on post-operative 7 days(P>0.05).Conclusion:Effect of preventing VTE of two methods of Rivaroxaban and intermit-tent pneumatic compression pump combined with elastic socks is quiter the same.After application of Rivaroxa-ban,effect of PT,APTT,AT,FIB and other blood coagulation function of patients are small.Clinical observa-tion was without bleeding complications and no increase risk of bleeding.And it has a significant advantage in the D dimer level control.