Experimental study on occurrence of phlebitis caused by infusion of aescinate with different concentrations and speeds

Long Lianyuan; Liu Weiqun; Chen Hongzhuo

doi:10.3969/j.issn.1009-6493.2016.01.015

Abstract：Objective:To probe into the relationship between the concentration and transfusion speed of the sodi-um aescinate and the ears venous blood vessels in the rabbit and observe the occurrence of ears phlebitis of rab-bit.Methods:The concentration and infusion rate of sodium aescinate were taken as the study factors,4 mg sodi-um aescinate was diluted into different concentrations(0.4 mg/mL,0.13 mg/mL)with 0.9% sodium chloride, and the normal saline was taken as the control group.At different infusion rate(80 gtt/min,50 gtt/min,30 gtt/min), 54 big ear rabbits were taken as the experimental objects,factorial design method was used for formation of 9 experimental groups with study factors for prospective randomized controlled study.After administration of 1 2 h,the obj ects were evaluated with phlebitis grading standards made by INS.Results:There was no phlebitis oc-curred in obj ects in normal saline groups with different infusion rate,but there was phlebitis occurred in admin-istration group.There was no statistically significant difference in the influence of different infusion rate with sodium aescinate on the incidence and the expression level of ears phlebitis of rabbit(P>0.05).there was statis-tically significant difference in the influence of the concentration on incidence of The difference was statistically significant(P<0.05),but there was a significant difference in the incidence of ears phlebitis(P<0.05).Conclu-sion:The main reason of the occurrence of phlebitis was the self effect of sodium aescinate.The infusion rate of sodium aescinate had no effect on the incidence and manifestations of phlebitis,concentration alone and interac-tion between concentration and infusion rate had effect for the incidence of phlebitis which suggested that the nursing staff can take measures to maintain normal infusion rate or speed up,so as to reduce the incidence of phlebitis induced by sodium aescinate.