Study on relationship between chronic helicobacter pylori infection degree and blood lipid metabolism in patients with heart disease

doi:10.3969/j.issn.10096493.2014.25.006

Abstract：Obj ective:To probe into the occurrence of helicobacter pylori (HP)infection in patients with coronary heart disease and its relation-ship with blood lipid metabolism.Methods:A total of 1 5 9 cases of in-formed consent of inpatients with coronary heart disease were selected and divided into HP infection group and HP non infection group based on the 14 C urea breath test results.The blood lipid level was measured, and the correlation was analyzed between the blood lipid level of CHD patients with helicobacter pylori (HP)infection and severity degree of coronary artery lesions.Results:The total serum cholesterol (TC),tri-glyceride(TG)and low density lipoprotein cholesterol(LDL C)levels in HP infection group were higher than that of HP non infection group,and the differences were statistically significant(P<0.05 or P<0.01);with the extent of HP infection aggravating in coronary artery disease patients,the TC,TG,LDL C levels also increased accordingly. There was statistically significant difference in serum TC,TG,LDL C level among patients with different degrees of HP infection(P<0.05 or P<0.01),serum high density lipoprotein cholesterol(HDL C)level decreased with the HP infection aggravated in CHD patients;the serum TC,TG,LDL C levels showed an increasing trend with increasing of severity of coronary artery lesions in HP infection patients.Serum HDL C level de-creased with increasing of severity of coronary artery lesions.Conclusion:HP infection may promote the formation of atherosclerosis through affecting the body lipid metabolism.It is the important risk factor of coronary atheroscle-rotic lesions,and then to induce coronary heart disease.