Influence of olive oil on lipid metabolism in hyperlipidemia rats and its antioxidative effect
Xu Qin’e
Zhang Nana
Abstract：Obj ective:To probe into the influence of olive oil on lipid me-tabolism in hyperlipidemia rats.Methods:A total of 50 adult male SD rats were randomly divided into normal control group,model control group and intervention group (rats in intervention group were divided in-to 3 subgroups,namely the low dose group,middle dose group,high dose group).The rats in all intervention subgroups received intragastric ad-ministration respectively with 5 mL/(kg·d),10 mL/(kg·d),20 mL/(kg·d) olive oil.And rats in normal control group and model control group re-ceived gavage with normal saline for 4 weeks.At the same time,rats ex-cept in normal control group were fed a high fat diet every day to estab-lish the model of hyperlipidemia rats.During the experiment,the basic situation of feeding and rats body weight change were observed and re-corded.After 4 weeks,blood samples were collected from the tail end and separation of serum was conducted.And superoxide dismutase in serum of rats(SOD),malondialdehyde(MDA),total cholesterol(TC),triglycer-ide(TG),high density lipoprotein cholesterol(HDL C),low density lip-oprotein cholesterol(LDL C)of all samples were determined.Results:Compared with the model group,MDA,TC,TG,LDL C decreased sig-nificantly in middle dose group of intervention group.And HDL C and SOD significantly increased.Conclusion:1 0 mL/kg olive oil intragastric administration can make the blood lipid level decline in hyperlipidemic rats,and can improve the antioxidant ability of the rats.
Keywords：olive oilhyperlipidemiato reduce blood fatratexperimen-tal study
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 2713-2715 )