Effects of Caragana Korshinskii tannins on growth performance,serum biochemical index,and immune function of finishing lambs fed high concentrate diet
CHEN Zhi-yu
NIU Xiao-yu
LI Hui
WANG Ya-ning
LI Rui-xue
LIU Pei-nan
XING Yuan-yuan
LI Da-biao
Abstract：The experiment aimed to investigate the effects of Caragana korshinskii tannins(CKT)on the growth performance,serum biochemical index,and immune function in finishing lambs fed high concentrate diet.Thirty 3-month-old Dumont crossbred male lambs were randomly divided into five treatment groups with six replicates per group and one sheep per replicate.The sheep were fed a low-concentrate diet(LC group),a high-concentrate diet(HC group),a high-concentrate diet with 0.1％CKT(HC+0.1％CKT group),a high-concentrate diet with 0.2％CKT(HC+0.2％CKT group),and a high-concentrate diet with 0.4％CKT(HC+0.4％CKT group).The pre-test period was 15 days and the formal test period was 45 days.The results showed that compared with HC group,the activities of serum aspartate aminotransferase(AST)and alanine aminotransferase(ALT)in HC+0.1％CKT and HC+0.2％CKT groups were significantly decreased(P＜0.05),and the serum urea nitrogen(BUN)and creatinine(CRE)concentrations in HC+0.1％CKT group were significantly decreased(P＜0.05).Serum cholesterol(TC)content in HC+0.2％CKT group was significantly decreased(P＜0.05).Compared with the HC group,mRNA expression levels of interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),Toll-like receptor 4(TLR-4),bone marrow differentiation factor 88(MyD88),and nuclear transcription factor-κB(NF-κB)in peripheral blood lymphocytes and serum IL-1β and interleukin-4(IL-4)were significantly decreased(P＜0.05),the mRNA expression of IL-4 was significantly increased(P＜0.05)in HC+0.1％CKT,HC+0.2％CKT,and HC+0.4％CKT groups.Serum immunoglobulin G(IgG),immunoglobulin M(IgM),and interleukin-10(IL-10)levels in HC+0.2％CKT and HC+0.4％CKT groups were significantly increased(P＜0.05).The results show that the appropriate dosage of CKT can improve the immune function of lambs and alleviate the organ damage caused by high concentrate,and the appropriate supplemental level of CKT was 0.2％under the experimental conditions.
Keywords：Caragana korshinskii tanninshigh concentrate dietlambsgrowth performanceimmune modulation
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 1-7 )