Study on antibacterial activity of 4-substituted tripyridyl cobalt and nickel
LUO Jia-qi
MA Cheng
HUANG Qing-ping
XIE Zhi-gang
JIANG Ming-sheng
LIU Hong-ming
CHEN Hai-lan
Abstract：The experiment aimed to study the antibacterial activity and mechanism of 4-substituted terpyridine cobalt and nickel complexes.The experiment used the two-fold dilution method to determine the minimum inhibitory concentration(MIC)of 10 different 4-substituted terpyridine cobalt and nickel metal complexes against six common pathogenic bacteria(Salmonella enterica,Staphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli K99,Streptococcus agalactiae,and Vibrio parahaemolyticus),and analyzed their antibacterial activity.The results showed that the complexes had good inhibitory effects on Staphylococcus aureus,with generally low MIC values,among which the MIC of LB3 NiCl2 against Staphylococcus aureus was as low as 5 mg/L.The growth curve and death curve of Staphylococcus aureus showed that LB3 NiCl2 inhibited bacterial growth to varying degrees and had concentration dependence.The results of fluorescence microscopy observation showed that the permeability of bacterial cell membranes increased after treatment with metal complexes.The study indicates that 4-substituted terpyridine cobalt and nickel complexes have good antibacterial activity against Staphylococcus aureus.
Keywords：terpyridinenickel complexesantibacterial activityStaphylococcus aureus
Publication Date：2024-10-31
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 86-90 )