Evidence summary of blood pressure management during intravenous thrombolysis in patients with acute ischemic stroke
He Lei
Xu Lei
Han Yujuan
Dong Aihua
Abstract：Objective To analyze the evidence on blood pressure management during intravenous thrombolysis in patients with acute ischemic stroke.Methods Evidence on target blood pressure management during intravenous thrombolysis in patients with acute ischemic stroke was electronically and systematically retrieved from China National Knowledge Infrastructure,WanFang Data,VIP,and China Biomedical Literature Database,PubMed,Cochrane Library,Embase,Web of Science,BMJ Best Practice,Ovid,UpToDate,and international authoritative websites,such as the Chinese Nursing Association,Guidelines International Network,National Institute for Health and Clinical Excellence,Scottish Intercollegiate Guidelines Network,American Stroke Association,Canadian Stroke Organization,and European Stroke Organisation.The search period was from the establishment of the database to April 30,2025.Two researchers independently conducted literature screening,quality evaluation,and evidence level assessment.Results A total of 14 articles were included,including 6 clinical guidelines,2 expert consensus,1 group standard,2 systematic reviews,1 evidence summary,1 clinical decision,and 1 best practice recommendation.A total of 23 pieces of evidence were extracted from 14 articles and integrated into 7 dimensions,including basic principles,control objectives,selection and maintenance of venous access,nursing of vasoactive drugs,nursing of thrombolytic drugs,blood pressure monitoring,and prevention and management of complications.Conclusions The evidence in this study mainly comes from domestic and international clinical guidelines,expert consensus,and clinical decision,with a high level of evidence and credibility.It is recommended that when conducting evidence transformation in clinical practice,factors such as the patient's age,underlying disease,and stroke time should be fully considered to selectively apply evidence,and scientifically manage the blood pressure during intravenous thrombolysis in patients with acute ischemic stroke,thereby improving patient prognosis.
Keywords：Acute ischemic strokeIntravenous thrombolysisBlood pressure managementEvidence-based nursingEvidence summary
Publication Date：2026-03-20
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：8( 184-191 )