Research progress on CLDN5 gene in depressive disorder
Li Mingshu
Zhang Lili
Li Keqing
Liu Miao
Zhang Yunshu
Abstract：Claudin 5(CLDN5)is a key structural component of intercellular tight junction proteins and has been identified as one of the most important intercellular tight junction proteins in the blood-cerebrospinal fluid barrier.Numerous studies have demonstrated that blood-cerebrospinal fluid barrier dysfunction is an important mechanism in the occurrence and progression of depressive disorder.CLDN5,one of the most important intercellular tight junction proteins in the blood-cerebrospinal fluid barrier,has also received much attention.This paper reviews the relationship between CLDN5 gene and the occurrence and treatment of depressive disorder,aiming to provide a reference for future research.
Keywords：CLDN5Depressive disorderReview
Publication Date：2026-02-20
Online Publishing Date：2026-03-11(First online date of this platform, not the publication date of the document)
Pages：5( 135-139 )