Research progress on the regulation of immune microenvironment in skull bone marrow and brain tumors
Li Jingyou
Ye Chengkun
Abstract：The initiation and progression of brain tumors are jointly regulated by multiple factors.In recent years,skull bone marrow—a crucial immunoregulatory microenvironment—has been increasingly recognized for its key regulatory role in brain tumors.Skull bone marrow not only directly participates in tumor immune evasion processes but also profoundly influences the remodeling of the tumor microenvironment and the efficacy of immunotherapy by regulating the recruitment and function of immune cells.However,the specific mechanisms by which skull bone marrow regulates the immune microenvironment of brain tumors remain largely unexplored.In-depth investigation into the role of skull bone marrow in brain tumors not only aids in understanding the dynamic changes within the tumor immune microenvironment but also provides new theoretical foundations for developing precise and effective immunotherapy strategies.This paper reviews the role of skull bone marrow in the immune microenvironment of brain tumors,focusing on its key functions in tumor immune evasion,immune microenvironment remodeling,and immunotherapy,while also exploring its potential for future clinical translation based on the latest research advances.
Keywords：Brain neoplasmsSkull bone marrowImmune microenvironmentImmune escapeTumor microenvironmentReview
Publication Date：2025-12-20
Online Publishing Date：2025-12-19(First online date of this platform, not the publication date of the document)
Pages：7( 865-871 )