Research progress on the mechanism of brain-gut axis in post-stroke gastrointestinal dysfunction
Dong Zhanchen
Wen Dingke
Yin Yao
Zhu Wei
Wang Cong
Jiang Yan
Abstract：Post-stroke gastrointestinal dysfunction is a consequence of an imbalance in the brain-gut axis involving autonomic dysfunction,amplified neuroinflammation,impaired intestinal barrier,and abnormal metabolism of flora.Abnormal bidirectional regulation between the central nervous system and the gastrointestinal tract allows gastrointestinal dysfunction and post-stroke neurologic damage to reinforce each other in a continuous pathological cycle.Recent studies targeting the brain-gut axis have revealed the potential roles of autonomic regulation,immune-inflammatory modulation and intestinal microecological repair in gastrointestinal dysfunction,providing new ideas for optimizing intervention strategies.Future research should further focus on the dynamic regulation mechanism of the brain-gut axis and explore the synergistic effects of multidimensional interventions,with the aim of providing precise theoretical support and therapeutic direction for the improvement of the brain-gut axis and the recovery of post-stroke neurological function.
Keywords：StrokeGastrointestinal dysfunctionBrain-gut axisIntestinal floraReview
Publication Date：2025-11-20
Online Publishing Date：2025-11-28(First online date of this platform, not the publication date of the document)
Pages：8( 829-836 )