Multi-omics testing and standardized clinical sample delivery process for glioma
Zhao Na
Cui Xiaoteng
Guo Hongbo
Kang Chunsheng
Li Jie
Abstract：Gliomas account for approximately 80%of all malignant intracranial tumors,with strong invasiveness and poor prognosis,posing significant challenges to clinical diagnosis and treatment.Traditional imaging and pathological grading often prove inadequate in addressing the significant intra-and intertumoral heterogeneity.Multi-omics(such as genomics,transcriptomics,proteomics,metabolomics)provide an integrated perspective for subtyping,risk stratification,and efficacy/recurrence monitoring,thereby accelerating the translation of novel therapies and precision medicine strategies into clinical applications for gliomas.However,challenges such as batch effects in sample preprocessing,inconsistent cross-platform standards,insufficient data integration and interpretability,and the integration of complex results into clinical pathways continue to hinder its implementation.This paper summarizes the key value and limitations of multi-omics testing in the practical context of precision diagnosis and treatment for gliomas,emphasizes standardized sample delivery,quality control,and reporting processes,providing guidance and recommendations for the clinical application of multi-omics testing.
Keywords：GliomaAccurate diagnosisMultiomicsStandards
Publication Date：2025-11-20
Online Publishing Date：2025-11-28(First online date of this platform, not the publication date of the document)
Pages：8( 761-768 )