The correlation between urine dry chemical indexes and Alzheimer-associated neuronal thread protein detection levels in the elderly population

Jin He; Chen Guodong; Zhao Li; He Jing; Wang Rong

doi:10.3969/j.issn.1009-6574.2025.07.003

Abstract：Objective To investigate the effects of urine dry chemical indexes on the detection level of Alzheimer-associated neuronal thread protein(AD7c-NTP)in the elderly population.Methods A total of 455 health examination subjects from the Affiliated Hospital of Guilin Medical University from July 2021 to March 2022 were selected as participants.Urine samples were collected,the concentration of AD7c-NTP were detected by enzyme-linked immunosorbent assay(ELISA),the urine dry chemical indicators were detected by dry chemical analyzer.Non-parametric test was used to analyze the effects of urine dry chemical indexes on AD7c-NTP levels,partial correlation test was used to analyze the correlation between urine dry chemical indexes and AD7c-NTP.Results The urine AD7c-NTP level in men was lower than that in women,and the difference was statistically significant(P＜0.05).There was significant difference in the level of AD7c-NTP among different age groups(P＜0.01).There were no significant differences in the levels of AD7c-NTP in different subgroups of pH,specific gravity,nitrite and glucose in male urine dry chemistry indexes(all P＞0.05);There were significant differences in AD7c-NTP levels among different subgroups of people with turbidity,occult blood,granulocyte esterase and urinary protein(all P＜0.05).There was no correlation between AD7c-NTP level and urine turbidity,pH value,specific gravity,nitrite,glucose in male urine dry chemical indicators(all P＞0.05);The level of AD7c-NTP was correlated with the degree of occult blood in urine,granulocyte esterase and urinary protein(all P＜0.05).There were no significant differences in the levels of AD7c-NTP in different subgroups of female urine dry chemical indicators,such as pH value,specific gravity,glucose and occult blood(all P＞0.05);The levels of AD7c-NTP in different subgroups of turbidity,nitrite,granulocyte esterase and urinary protein were significantly different(all P＜0.05).There was no correlation between urine pH,specific gravity,glucose and AD7c-NTP levels in female(all P＞0.05);Urine turbidity,nitrite,occult blood,granulocyte esterase and urine protein were correlated with AD7c-NTP levels(all P＜0.05).Conclusions The urine nitrite,occult blood,granulocytic esterase and protein of dry chemical indexes were correlated with AD7c-NTP,the interpretation of AD7c-NTP detection results in clinical application should refer to urine dry chemical indexes.