Related factors of suicide risk in hospitalized late life depression at acute phase
Zhen Wenfeng
Yang Jing
Wang Xiao
Ma Xianglin
Zhang Qing'e
Abstract：Objective To compare the clinical characteristics of hospitalized patients with late life depression(LLD)at different suicide risks in the acute phase,and explore the related factors of suicide risks.Methods A retrospective analysis was conducted on 118 patients with LLD at risk of suicide,admitted to Beijing Anding Hospital,Capital Medical University during acute phase from July 2021 to December 2022,including 65 with suicidal ideation(suicidal ideation group)and 53 with attempted suicide behaviour(attempted suicide group).The general clinical data,and the scores of Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale-24(HAMD-24)were compared.The following pathology results among patients in different groups were compared,including adrenocorticotropic hormone(ACTH),cortisol,serum total thyroxine(TT4),triiodothyronine(T3),free triiodothyronine(FT3),free thyroxine(FT4),thyroid-stimulating hormone(TSH),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),estradiol,testosterone,etc.The related factors of attempted suicide in hospitalized LLD patients were analyzed by binomial logistic regression.Results Compared with the suicide ideation group,the FT3 level was lower in the attempted suicide group.Compared with the suicide ideation group,the TSH value,HAMD-24 total score,cognitive impairment factor score,despair factor score,and HAMA anxiety factor score were higher in the attempted suicide group,and the differences were statistically significant(P＜0.05).The results of the binomial logistic regression analysis showed that,FT3(OR=0.410,P=0.019)、Psychological anxiety factor(OR=1.192,P=0.029)are related risk factors for attempted suicide in hospitalized LLD patients.Conclusions Compared with patients with suicidal ideation in LLD,hospitalized LLD patients with attempted suicide have lower thyroid function levels and more severe depressive symptoms.FT3 levels and psychological anxiety factors are related factors for attempted murder in hospitalized LLD patients.
Keywords：Late life depressionHospitalizationSuicide riskClinical characteristicsRisk factor
Publication Date：2024-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 837-843 )