Application of FK506 binding protein 5 gene in the treatment of mood disorders
Zhang Jiakai
Sang Wenhua
Guo Zhenbo
Zhang Zhenyu
Abstract：The occurrence of mood disorders is related to the dysfunction of the hypothalamic-pituitary-adrenal(HPA)axis.FK506-binding protein 5(FKBP5),a glucocorticoid receptor(GR)chaperone protein,regulates HPA axis function by regulating GR sensitivity.This article reviews FKBP5 gene and its application in drug therapy,electroconvulsive therapy,psychotherapy and FKBP5 antagonists in mood disorders.
Keywords：Depressive disorderBipolar disorderFK506-binding protein 5TreatmentReview
Publication Date：2024-10-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 757-760 )