Research progress on the involvement of dopamine reward system input regulation in the mechanism of depressive disorder
Yang Lu
Zhang Yi
Peng Jintao
Jiang Yuting
Cui Minghu
Abstract：Anhedonia is one of the core symptoms of depressive disorder,and the dopaminergic system plays a crucial role in the occurrence of anhedonia.Dopaminergic activity is highly complex and regulated by various brain structures,including the ventral subiculum,nucleus accumbens,ventral pallidum,and basolateral amygdala.Basic and clinical studies have shown that dopaminergic system defects in depressive disorder can be attributed to dysregulation of the input circuit.This paper starts with the correlation between depressive disorder and dopaminergic system,and summarizes the upstream pathways of dopaminergic neurons in the ventral tegmental area,including the activation pathway from the ventral subiculum to the nucleus accumbens to the ventral pallidum,and the inhibition pathway from the basolateral amygdala to the ventral pallidum.Moreover,this paper objectively elucidates depressive-like behavior and abnormal input regulation of the midbrain dopaminergic system in depressive disorder through basic experiments and clinical studies,and outlines the correlation between antidepressant treatment and midbrain dopaminergic nervous system,so as to provide directions for the diagnosis,treatment,and mechanism research of depressive disorder.
Keywords：DopamineDepressive disorderVentral tegmental areaInput regulationReview
Publication Date：2024-06-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 441-446 )