Research progress on vascular endothelial growth factor in improving cognitive dysfunction in Alzheimer disease
Wang Huan
Tang Yao
Huang Fengqin
Luo Xingmei
Abstract：Cellular senescence and abnormal glucose metabolism in the brain are early features of Alzheimer's disease(AD),and this feature may precede β-amyloid deposition or tau phosphorylation.Vascular endothelial growth factor(VEGF)can alleviate cognitive dysfunction in AD patients by nourishing nerves,improving glucose metabolism in the brain,and resisting toxic effects of β-amyloid on neurons.This paper reviews the mechanism of VEGF in improving cognitive dysfunction in AD patients,so as to deepen clinical understanding of the disease and provide reference for exploring new therapeutic targets and methods.
Keywords：Alzheimer diseaseVascular endothelial growth factorsCognitionGlucose metabolismMitochondriaReview
Publication Date：2024-04-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 288-293 )