Research progress on impulse control disorders induced by third-generation antipsychotics
Chen Lihe
Guo Qian
Liu Xiaohua
Li Guanjun
Abstract：Impulse control disorders(ICDs)are a group of mental disorders in which one repeatedly experiences behaviors that they cannot control and harm others'or their own interests without reasonable motivation.ICDs include pathological gambling,hypersexuality,compulsive shopping,compulsive eating and so on,which cause serious burdens on patients themselves,their families,and society.Third-generation antipsychotics(TGAs),including aripiprazole,brepiprazole,and caliprazine,with agonism or partial agonism on dopamine D2 and D3 receptors and 5-hydroxytryptamine 1A receptor,may induce ICDs.However,there are still limitations in clinical practice,such as insufficient identification,unclear screening tools,and limited interventions,and disease awareness and intervention for TGA-induced ICDs need to be further improved.This paper reviews the epidemiology,risk factors,physiological mechanisms,clinical evaluation,diagnosis,and treatment of TGAs-induced ICDs,in order to enhance clinicians'understanding of this disease and adopt appropriate treatments to alleviate patients'pain and improve disease prognosis.
Keywords：Impulse control disordersThird-generation antipsychoticsAripiprazoleBrexpiprazoleCariprazineReview
Publication Date：2024-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 121-127 )