Research progress of interleukin-6 in the pathogenesis and clinical treatment of depression
Yao Lixia
Jia Haozhi
Tian Feng
Abstract：Depressive disorder is a kind of affective disorder,and its pathogenesis involves multiple factors.Inflammation may be one of the pathophysiological mechanisms underlying depressive disorder.Currently,studies have shown changes in interleukin-6(IL-6)in patients with depressive disorder.This paper summarizes the pathogenesis of IL-6 and depressive disorder,as well as the role of IL-6 in different clinical treatment methods,and explores the role of IL-6 in the occurrence and prognosis of depression,providing reference for further elucidating the activity patterns and mechanisms of IL-6 in the pathogenesis of depressive disorder.
Keywords：Depressive disorderInterleukin-6Signal transductionReview
Publication Date：2023-12-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 869-873 )