Analysis of neurobiochemical markers associated with cognitive dysfunction in patients with depression
Hu Quanxi
Yang Xueling
Wang Demin
Wen Jinfeng
Abstract：Objectives? To study the association between neurobiochemical markers and cognitive dysfunction in patients with depression. Methods? Patients with depression were divided into cognitive dysfunction group and normal cognitive function group according to the Chinese version of Montreal Cognitive Assessment (MoCA). Multivariate analysis was performed with binary logistic regression model to identify the association between serum homocysteine (Hcy), corticoid (COR), dehydroepiandrosterone (DHEA), interleukin-18 (IL-18), brain-derived neurotrophic factor (BDNF) and cognitive dysfunction in patients with depression. Results? After adjusting for gender, age, educational years and the 24-item Hamilton Depression Scale (HAMD-24) scores, serum Hcy, COR, DHEA and IL-18 were associated with cognitive dysfunction in patients with depression, and their odds ratio (OR) were 2.458 (95%CI: 1.343-4.918), 2.034 (95%CI: 1.217-4.837), 1.954 (95%CI: 1.122-4.129) and 2.173 (95%CI: 1.226-4.909), respectively. Conclusions? Serum Hcy, COR, DHEA, and IL-18 were associated with cognitive dysfunction in patients with depression, which might be used in the prediction of cognitive dysfunction in patients with depression.
Keywords：DepressionCognitive dysfunctionNeurobiochemical markers
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 382-385 )