Relationship between serum BMP-7 and acute cerebral infarction

Kang Kai; Nao Jianfei

doi:10.3969/j.issn.1009-6574.2019.03.015

Abstract：Objective? To investigate the relationship between bone morphogenetic protein-7 (BMP-7) level and the severity and prognosis of patients with acute cerebral infarction (ACI). Methods? A total of 105 patients with ACI (ACI group) and 105 healthy people (control group) were recruited from September 2017 to March 2018. The serum BMP-7 level was measured and the clinical data of all patients were recorded. The patients in ACI group were followed up for 3 months and their Modified Rankin Scores (mRS) were recorded. The difference of BMP-7 level in ACI group and healthy control group, and the relationship between BMP-7 level and severity and prognosis in ACI group were observed. Results? The level of BMP-7 in ACI group was lower than that in the control group. The result of Logistic regression showed that smoking, hypertension, diabetes, coronary heart disease, cystatin C, glycosylated hemoglobin, and BMP-7 levels are closely related to the incidence of ACI (P＜ 0.05). The level of BMP-7 in less severe ACI group was 61.54(58.46,66.32), which was higher than that in severe group 54.69(51.18,58.27). The level of BMP-7 was negatively correlated with the score of the National Institutes of Health Stroke Scale (NIHSS) (r=-0.702,P＜ 0.05). The level of BMP-7 in patients with poor prognosis was lower than that in patients with good prognosis (P＜ 0.05). There was a negative correlation between the level of BMP-7 and mRS score of ACI patients (r=-0.493,P＜ 0.05). Conclusions? BMP-7 is an influential factor in the pathogenesis of ACI, and the level of BMP-7 can be used to evaluate the severity of ACI and predict the prognosis of patients with ACI.