Effect of vagus nerve stimulation by clectroacupuncture on the expression level of inflammatory factors in adolescent depression patients
Yang Chao
Yang Xiaoying
Zhang Li
Wang Yuan
Wang Yan
Yang Ping
Abstract：Objective? To explore the effects of vagus nerve stimulation by electroacupuncture on clinical efficacy and expression level of inflammatory factors in adolescent depression patients. Methods? A total of 78 adolescent depression patients were randomly divided into experimental (vagus nerve stimulation by electroacupuncture + Sertraline, n=40) and control group (Sertraline, n=38). All the patients were evaluated at the baseline and 4 weeks after treatment. The Positive and Negative Syndrome Scale (PANSS) and Hamilton Depression Scale (HAMD-17) were applied to evaluate efficacy. ELISA was used to detect the expression level of IL-1α,TNF-α,IL-6,IL-2. Results? The effective rate of the experimental group was 80.0% (32/40), and that of the control group was 57.9% (22/38). The difference was statistically significant (χ2=4.470,P=0.034). The negative factor, the general psychopathology and the total score of PANSS and the total score of HAMD-17 of the 2 groups all decreased than before treatment (P＜0.05). The general psychopathology and the total score of PANSS and the total score of HAMD-17 of the experimental group were lower than those of the control group (P＜0.05). IL-1α,TNF-α,IL-6, IL-2 of the experimental group decreased than before the treatment and those of the control group after treatment (P＜0.05). Conclusions? Vagus nerve stimulation by electroacupuncture can improve depressive symptoms in adolescents, possibly by reducing the level of inflammatory factors.
Keywords：Depression? Adolescent? Electroacupuncture? Vagus nerve? Inflammatory factors
Publication Date：2019-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 44-47 )