Study on the regional homogeneity of resting brain MRI in first-episode depression
Sun Hongyan
Liu Haihua
Gu Miaomiao
Wang Lei
Zhang Yuan
Abstract：Objective To explore the changes of brain function in the specific brain regions of first-episode depressive patients using resting state magnetic resonance imaging (MRI) technology. Methods Resting state MRI examination was performed on 20 patients who met the diagnostic criteria of depression and 20 healthy volunteers. The resting state MRI regional homogeneity (ReHo) was used to compare the ReHo values of the depression group, to find brain regions with increased or reduced specificity. Results Compared with the control group, the brain areas with increased ReHo were posterior cerebellar lobe, inferior temporal gyrus, middle occipital gyrus, lingual gyrus, posterior central gyrus, anterior central gyrus, superior frontal gyrus and parietal lobe. While ReHo decreased in marginal lobe, parahippocampal gyrus, putamen, thalamus, lenticular nucleus, inferior frontal gyrus, middle frontal gyrus, anterior cuneiform lobe and cingulate gyrus. Conclusions ReHo analysis of resting state MRI may discover abnormal brain regions of depression, which may help to explore the pathogenesis of depression.
Keywords：Depressive disorderMagnetic resonance imagingresting stateRegional homogeneity
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 784-787,封3 )