3.0T magnetic resonance spectroscopy study on hippocampus in postnatal depression patients
Lu Huiqun
Xu Caixia
Xu Xiaojie
Ye Bo
Wang Jintao
Yin Chengying
Abstract：Objective To explore the neurochemical changes of the hippocampus in the patients with postnatal depression. Methods A total of 20 postnatal depression patients and 20 postnatal healthy controls were recruited, and the hippocampal head, body and tail were evaluated by magnetic resonance spectroscopy (1H-MRS). The indicators included N-acetylaspartic acid (NAA), choline complex (Cho), creatine (Cr), inositol (MI), and calculated the ratio. Results The values of NAA/Cr in the bilateral hippocampal head, body of the postnatal?depression patients were significantly higher than the health controls (P＜ 0.05), while there was no significant difference in the hippocampal tail between the two groups (P＞0.05). There were no significant differences in the value of Cho /Cr in the hippocampal head, body or tail between the two groups (P＞0.05). The value of MI/Cr in the bilateral hippocampal head of the postnatal depression patients was significantly decreased than the health controls (P＜0.05), while there was no significant difference in the hippocampal tail between the two groups (P＞0.05). Conclusions Metabolism of hippocampus in patients with postpartum depression changes, which may constitute the neurobiological basis of postpartum depression.
Keywords：Postnatal depressionHippocampusMagnetic resonance spectroscopy
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 714-717 )