Abnormal internal function connectivity of salience network in obsessive-compulsive disorder at resting-state
Lyu Dan
Li Ping
Wang Lihong
Chen Yunhui
Wang Yuhua
Zhao Ameng
Li Chengchong
Yan Fengwu
Song Yunna
Wang Wenlin
Zhang Liangtang
Abstract：Objective To explore the characteristic of internal function connectivity in salience network and its relationship with clinical symptoms in untreated obsessive-compulsive disorder (OCD) patients at resting-state. Methods A total of 20 untreated OCD patients and 20 age-, sex- and education-matched healthy subjects participated in the resting state brain functional magnetic resonance imaging scan. Based on the Data Processing & Analysis for (Resting-State) Brain Imaging (DPABI) software, functional connectivity based on seed was used to explore the pattern of salience network at resting-state in OCD. Partial correlation analysis was used to analyze the relationship between the salience network and clinical symptoms in OCD. Results Compared with the healthy controls, the OCD patients showed decreased internal function connectivity in salience network in left orbitofrontal cortex [(0.08±0.09) vs (0.27±0.07);t=-7.80,P<0.001, Gaussian random field corrected, two-tailed]. Conclusions There is an abnormal function connection of salience network internal in OCD at resting-state.
Keywords：Obsessive-compulsive disorderFunctional magnetic resonance imagingResting stateSalience network
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 94-97,后插1 )