Research progress on the effects of growth differentiation factor-15 on neurological systems
Yu Yan
Duan Shurong
Abstract：Growth differentiation factor-15 (GDF-15) is a new divergent member of the transforming growth factor-β (TGF-β) superfamily. Research on GDF-15 is currently focused on its anti-inflammatory, anti-cell proliferation, and inhibition of tumor growth. In the nervous system, researchers found that GDF-15 is a protective factor for nigral dopaminergic neurons, a new trophic factor for motor and sensory neurons, a predictor of cerebrovascular disease and brain damage. Recent studies have shown that GDF-15 also has the function of modulating the expression of neuronal ion channels and affecting the function of synaptic transmission. This review summarizes the biological characteristics of GDF-15 and its recent advances in neurological diseases.
Keywords：Growth differentiation factor-15Cerebral infarctionCognition disordersParkinson diseaseReview
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 66-69 )