Effects of high-flux hemodialysis on the depression state in maintenance hemodialysis patients

doi:10.3969/j.issn.1009-6574.2017.10.008

Abstract：Objective To explore the effects of high-flux hemodialysis (HFHD) and convention hemodialysis (CHD) on depression level and concentration of interleukin-6 (IL-6), homocysteine (Hcy), malondialdehyde (MDA), superoxide dismutase (SOD) in the serum of maintenance hemodialysis (MHD) patients. Methods A total of 72 MHD patients were divided into HFHD group and CHD group randomly, with 36 patients in each. Before treatment and 6 months after, all the participants were estimated for depression score and concentration of IL-6, Hcy, MDA, SOD in serum when dry weight was reached after dialysis. Results Before treatment, there was no intergroup statistical difference in depression score, concentration of IL-6, Hcy, MDA, SOD in serum (P> 0.05) between the two groups. After 6-month treatment, the depression score and the serum concentration of IL-6, Hcy, MDA in HFHD group decreased significantly (P<0.05), and the SOD concentration increased (P<0.05). There was no noticeable change of all the indicators of CHD group compared with those before treatment (P>0.05). The depression score and the level of serum IL-6, Hcy, MDA in group HFHD decreased compared with CHD group, and the SOD concentration increased as well (P<0.05). Analysis showed that there was a positive correlation between depression score and IL-6, Hcy, MDA level(r=0.367, 0.463,0.769, respectively). The correlation between depression score and SOD level was negative(r=-0.571). Conclusions HFHD can alleviate depression states by eliminating IL-6,Hcy,MDA more efficiently and increasing SOD level than CHD in MHD patients.