Meaning of re-evaluation for clinical dementia diagnosis by brain PET imaging and CSF test
Abstract：Objective To find better diagnostic methods and criteria by re-evaluation for initial clinical dementia diagnosis. Methods Totals of 22 subjects diagnosed as mild neurodegenerative non-vascular dementia from June 2011 to June 2012 were included. Brain PIB and FDG PET, CSF test and neuropsychological tests were assessed in all patients. MMSE test was measured every 1-2 years untill April 2017. Results The diagnosis of 7 out of 22 subjects was changed. 4 patients diagnosed with Alzheimer disease (AD) changed to dementia with Lewy bodies (DLB), while 2 AD patients and 1 behavioural variant frontotemporal dementia (bvFTD) patient changed to unspecified dementia (UNS). There were significant differences between changed and non-changed team in educational level, Aβ42concentration, comprehension test, episodic memory test and reductions in regional cerebral glucose metabolism (P<0.05). Conclusions Brain PET imaging and CSF test have guiding significance for re-evaluation for clinical dementia diagnosis.
Keywords：DementiaDeoxyglucosePittsburgh compound BPositron emission tomographyCerebrospinal fluid
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 478-482 )